Haensel-Hertsch Lab: Home

Hänsel-Hertsch Lab

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Deciphering (Epi)Genome structure and stability

Laboratory For Genome Biology

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PhD and technical assistant positions available - cancer targeting (CANTAR) - single-cell omics - apply until 30th of November 2022

Curious about actionability of epigenetic alterations in cancer? To address relationships, you will focus on the development and application of single-cell omics technologies. We highly encourage interested individuals from Ukraine to apply. Please contact robert.haensel-hertsch@uni-koeln.de

Fritz Thyssen Foundation supports our project on HGPS and mesenchymal stromal cell aging

We are delighted to receive generous funding by the Fritz Thyssen Foundation to support our endeavours on understanding epigenetic alterations and their interconnection to genome instability in mesenchymal stromal cells derived from human patients and mouse models of the Hutchinson-Gilford progeria…

New paper in Genome Research: Ultrashort cell-free DNA with G-quadruplex potential depleted in cancer patients

To our surprise, cancer patients are particularly depleted of ultrashort cell-free DNA (US cfDNA) with the potential to adopt G-quadruplex structures in nucleosome-depleted gene promoter elements.

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Our lab explores the existence and significance of epigenome structural alterations and its impact on disease development. Hence, the structure of the genome may significantly change with age and disease development, such as cancer or degenerative diseases. Additionally, we are exploring whether defined age- or cancer-related epigenome structural alterations are of diagnostic and therapeutic value.

Selected Publications

P. Hunold*, M.N. Hoehne*, M. Kiljan, O. van Ray, J. Herter, G.S. Herter-Sprie, R. Hänsel-Hertsch
G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments
bioRxiv 2023 doi.org/10.1101/2023.01.16.524243
I. Hudecova*, C.G. Smith*, R. Hänsel-Hertsch*, C. Chilamakuri, J.A. Morris, A. Vijayaraghavan, K. Heider, D. Chandrananda, W.N. Cooper, D. Gale, J. Garcia-Corbacho, S. Pacey, R.D. Baird, N. Rosenfeld, F. Mouliere
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Genome Research (2021), DOI:10.1101/gr.275691.121
R. Hänsel-Hertsch, A. Simeone, A. Shea, W.W.I. Hui, K.G. Zyner, G. Marsico, O.M. Rueda, A. Bruna, A. Martin, X. Zhang, S. Adhikari, D. Tannahill, C. Caldas, S. Balasubramanian
Landscape of G-quadruplex DNA structural regions in breast cancer
Nature Genetics (2020), 52: 878–883
R. Hänsel-Hertsch*, J. Spiegel*, G. Marsico, D. Tannahill, S. Balasubramanian
Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
Nature Protocols (2018), 13: 551-564
R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
G-quadruplex structures mark human regulatory chromatin
Nature Genetics (2016), 10: 1267-72

*contributed equally

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