Longitudinal study of mRNA vaccination against SARS-CoV-2 establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory. Promoters are enriched for G4-DNA forming sequences. --> www.embopress.org/doi/full/10.1038/s44320-025-00093-6