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Deciphering (Epi)Genome structure and stability

Laboratory For Genome Biology

Our lab ex­plores the ex­ist­ence and sig­ni­fic­ance of epi­gen­ome struc­tur­al al­ter­a­tions and its im­pact on dis­ease de­vel­op­ment. Hence, the struc­ture of the gen­ome may sig­ni­fic­antly change with age and disease development, such as can­cer or de­gen­er­at­ive dis­eases. Ad­di­tion­ally, we are ex­plor­ing wheth­er defined age- or can­cer-re­lated epi­gen­ome struc­tur­al al­ter­a­tions are of dia­gnost­ic and thera­peut­ic value.

Selected Publications

  • R. Hänsel-Hertsch, A. Simeone, A. Shea, W.W.I. Hui, K.G. Zyner, G. Marsico, O.M. Rueda, A. Bruna, A. Martin, X. Zhang, S. Adhikari, D. Tannahill, C. Caldas, S. Balasubramanian
    Landscape of G-quadruplex DNA structural regions in breast cancer
    Nature Genetics (2020), 52: 878–883
  • R. Hänsel-Hertsch, J. Spiegel, G. Marsico, D. Tannahill, S. Balasubramanian
    Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
    Nature Protocols (2018), 13: 551-564
  • R. Hänsel-Hertsch, M. Di Antonio, S. Balasubramanian
    DNA G‑quadruplexes in the human genome: detection, functions and therapeutic potential
    Nature Reviews Molecular Cell Biology (2017), 18: 279-284
  • R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
    G-quadruplex structures mark human regulatory chromatin
    Nature Genetics (2016), 10: 1267-72
  • S.V. Lensing, G. Marsico, R. Hänsel-Hertsch, E.Y. Lam, D. Tannahill, S. Balasubramanian
    DSBCapture: in situ capture and sequencing of DNA breaks
    Nature Methods (2016), 10: 855-7