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Deciphering (Epi)Genome structure and stability

Laboratory For Genome Biology

Our lab ex­plores the ex­ist­ence and sig­ni­fic­ance of age-re­lated epi­gen­ome struc­tur­al al­ter­a­tions and its im­pact on dis­ease de­vel­op­ment. Hence, the struc­ture of the gen­ome may sig­ni­fic­antly change with age and pre­dis­pose mam­mals to dis­ease de­vel­op­ment, such as can­cer or de­gen­er­at­ive dis­eases. Ad­di­tion­ally, we are ex­plor­ing wheth­er defined age- or can­cer-re­lated epi­gen­ome struc­tur­al al­ter­a­tions are of dia­gnost­ic and thera­peut­ic value.

Selected Publications

  • R. Hänsel-Hertsch, J. Spiegel, G. Marsico, D. Tannahill, S. Balasubramanian
    Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
    Nature Protocols (2018), 13: 551-564
  • R. Hänsel-Hertsch, M. Di Antonio, S. Balasubramanian
    DNA G‑quadruplexes in the human genome: detection, functions and therapeutic potential
    Nature Reviews Molecular Cell Biology (2017), 18: 279-284
  • R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
    G-quadruplex structures mark human regulatory chromatin
    Nature Genetics (2016), 10: 1267-72
  • S.V. Lensing, G. Marsico, R. Hänsel-Hertsch, E.Y. Lam, D. Tannahill, S. Balasubramanian
    DSBCapture: in situ capture and sequencing of DNA breaks
    Nature Methods (2016), 10: 855-7
  • R. Hänsel, F. Löhr, L. Trantirek, V. Dötsch
    High-resolution insight into G-overhang architecture
    Journal of the American Chemical Society (2013), 135: 2816-24