Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag. #DynaTag can reveal nuanced TF occupancy behaviour and shed light on transcriptional regulation in health and disease. In small cell lung cancer #SCLC PDX models, it uncovered surprising…

Longitudinal study of mRNA vaccination against SARS-CoV-2 establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory. Promoters are enriched for G4-DNA forming sequences. -->…

Giulia Pizzolato received prestigious Alexander von Humboldt Fellowship to conduct her Postdoc work on small cell lung cancer. AvH will support Giulia from June 2025 onwards.

Our hypothesis on the context of how G4 DNA structure may cause genome instability

Curious about actionability of epigenetic alterations in cancer? To address relationships, you will focus on the development and application of single-cell omics technologies. We highly encourage interested individuals from Ukraine to apply. Please contact robert.haensel-hertsch@uni-koeln.de

We are delighted to receive generous funding by the Fritz Thyssen Foundation to support our endeavours on understanding epigenetic alterations and their interconnection to genome instability in mesenchymal stromal cells derived from human patients and mouse models of the Hutchinson-Gilford progeria…

To our surprise, cancer patients are particularly depleted of ultrashort cell-free DNA (US cfDNA) with the potential to adopt G-quadruplex structures in nucleosome-depleted gene promoter elements.

The central scientific goal for the second funding period is to map and catalogue potentially actionable interactions between molecularly characterized individual cancer cells and their TME, with a particular focus on understanding anti-cancer immune responses

Our recent observation suggests that G4 DNA secondary structure marks critical biology of breast cancer and is of diagnostic and therapeutic value.