Publications
The fruit derived from labor is the sweetest of pleasures
Publications
Selected Publications
- P. Hunold, G. Pizzolato, N. Heramvand, L. Kaiser, G. Barbiera, O. van Ray, R. Thomas, J. George, M. Peifer, R. Hänsel-Hertsch
DynaTag profiles dynamics of transcription factor-DNA binding for low-input samples and at single-cell resolution
Nat Commun (2025), https://www.nature.com/articles/s41467-025-61797-9 - A. Simonis, S. J Theobald, A. E. Koch, R. Mummadavarapu, J. M. Mudler, A. Pouikli, U. Göbel, R. Acton, S. Winter, A. Albus, D. Holzmann, M.-C. Albert, M. Hallek, H. Walczak, T. Ulas, M. Koch, P. Tessarz, R. Hänsel-Hertsch# and J. Rybniker#
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Mol Syst Biol (2025), https://doi.org/10.1038/s44320-025-00093-6 - I. Hudecova*, C.G. Smith*, R. Hänsel-Hertsch*, C. Chilamakuri, J.A. Morris, A. Vijayaraghavan, K. Heider, D. Chandrananda, W.N. Cooper, D. Gale, J. Garcia-Corbacho, S. Pacey, R.D. Baird, N. Rosenfeld, F. Mouliere
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Genome Research (2022), DOI:10.1101/gr.275691.121 - R. Hänsel-Hertsch, A. Simeone, A. Shea, W.W.I. Hui, K.G. Zyner, G. Marsico, O.M. Rueda, A. Bruna, A. Martin, X. Zhang, S. Adhikari, D. Tannahill, C. Caldas, S. Balasubramanian
Landscape of G-quadruplex DNA structural regions in breast cancer
Nature Genetics (2020), 52: 878–883 - R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
G-quadruplex structures mark human regulatory chromatin
Nature Genetics (2016), 10: 1267-72
*contributed equally
#co-corresponding
2025
- P. Hunold, G. Pizzolato, N. Heramvand, L. Kaiser, G. Barbiera, O. van Ray, R. Thomas, J. George, M. Peifer, R. Hänsel-Hertsch
DynaTag profiles dynamics of transcription factor-DNA binding for low-input samples and at single-cell resolution
Nat Commun (2025), https://www.nature.com/articles/s41467-025-61797-9 - A. Simonis*, S. J Theobald*, A. E. Koch, R. Mummadavarapu, J. M. Mudler, A. Pouikli, U. Göbel, R. Acton, S. Winter, A. Albus, D. Holzmann, M.-C. Albert, M. Hallek, H. Walczak, T. Ulas, M. Koch, P. Tessarz, R. Hänsel-Hertsch*# and J. Rybniker*#
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Mol Syst Biol (2025), https://doi.org/10.1038/s44320-025-00093-6 - J. Frobel, R. Hänsel-Hertsch
The age-related decline of helicase function: how G-quadruplex structures promote genome instability
FEBS Letters (2025), DOI:10.1002/1873-3468.14939
*contributed equally
#co-corresponding
2024
- P.V. Sauer, E. Pavlenko, T. Cookis, L.C. Zirden, J. Renn, A. Singhal, P. Hunold, M.N. Hoehne-Wiechmann, M. Kiljan, O. van Ray, F. Kaschani, M. Kaiser, R. Hänsel-Hertsch, K.Y. Sanbonmatsu, E. Nogales and S. Poepsel
Activation of automethylated PRC2 by dimerization on chromatin
Mol Cell (2024) DOI: 10.1016/j.molcel.2024.08.025
2023
- P. Hunold*, M.N. Hoehne*, M. Kiljan, O. van Ray, J. Herter, G.S. Herter-Sprie, R. Hänsel-Hertsch
G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments
bioRxiv 2023 doi.org/10.1101/2023.01.16.524243
*contributed equally
2022
- I. Hudecova*, C.G. Smith*, R. Hänsel-Hertsch*, C. Chilamakuri, J.A. Morris, A. Vijayaraghavan, K. Heider, D. Chandrananda, W.N. Cooper, D. Gale, J. Garcia-Corbacho, S. Pacey, R.D. Baird, N. Rosenfeld, F. Mouliere
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Genome Research (2022), DOI:10.1101/gr.275691.121
*contributed equally
2021
- J. Spiegel, S.M. Cuesta, S. Adhikari, R. Hänsel-Hertsch, D. Tannahill, S. Balasubramanian
G-quadruplexes arę transcription factor binding hubs in human chromatin
Genome Biology (2021), DOI:10.1186/s13059-021-02324-z
2020
- R. Hänsel-Hertsch, A. Simeone, A. Shea, W.W.I. Hui, K.G. Zyner, G. Marsico, O.M. Rueda, A. Bruna, A. Martin, X. Zhang, S. Adhikari, D. Tannahill, C. Caldas, S. Balasubramanian
Landscape of G-quadruplex DNA structural regions in breast cancer
Nature Genetics (2020), 52: 878–883 - P. Broft, S. Dzatko, M. Krafcikova, A. Wacker, R. Hänsel‐Hertsch, V. Dötsch, L. Trantirek, H. Schwalbe
In‐Cell NMR Spectroscopy of Functional Riboswitch Aptamers in Eukaryotic Cells
Angew. Chemie Int. Ed. (2020), 60: 865–872
2019
- M. Krafcikova, S. Dzatko, C. Caron, A. Granzhan, R. Fiala, T. Loja, MP. Teulade-Fichou, T. Fessl, R. Hänsel- Hertsch, JL Mergny, S. Foldynova-Trantirkova, L. Trantirek
Monitoring DNA-Ligand Interactions in Living Human Cells Using NMR Spectroscopy
Journal of the American Chemical Society (2019), 34: 13281-13285 - M. Krafcikova, R. Hänsel-Hertsch, L. Trantirek, S. Foldynova-Trantirkova
In Cell NMR Spectroscopy: Investigation of G-Quadruplex Structures Inside Living Xenopus laevis Oocytes
Methods in Molecular Biology (2019), doi: 10.1007/ 978-1-4939-9666-7_25
2018
- A. Parry, M. Hoare, D. Bihary, R. Hänsel-Hertsch, S. Smith, K. Tomimatsu, S. Balasubramanian, H. Kimura, S. Samarajiwa, M. Narita
NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Nature Communications (2018), 9: 1840 - S. Mao, A. T. Ghanbarian, J. Spiegel, S. Martínez Cuesta, D. Beraldi, M. Di Antonio, G. Marsico, R. Hänsel- Hertsch, D. Tannahill, S. Balasubramanian
DNA G-quadruplex structures mould the DNA methylome
Nature Structure & Molecular Biology (2018), 25: 951-957 - R. Hänsel-Hertsch, J. Spiegel, G. Marsico, D. Tannahill, S. Balasubramanian
Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing
Nature Protocols (2018), 13: 551-564
2017
- S. Dzatko, M. Krafcikova, R. Hänsel-Hertsch, T. Fessl, R. Fiala, T. Loja, D. Krafcik, JL Mergny, S. Foldynova- Trantirkova, L. Trantirek
Evaluation of stability of DNA i-motifs in the nuclei of living mammalian cells
Angewandte Chemie International Edition (2017), doi: 10.1002/anie.201712284 - R. Hänsel-Hertsch, M. Di Antonio, S. Balasubramanian
DNA G‑quadruplexes in the human genome: detection, functions and therapeutic potential
Nature Reviews Molecular Cell Biology (2017), 18: 279-284
2016
- S.V. Lensing, G. Marsico, R. Hänsel-Hertsch, E.Y. Lam, D. Tannahill, S. Balasubramanian
DSBCapture: in situ capture and sequencing of DNA breaks
Nature Methods (2016), 10: 855-7 - R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
G-quadruplex structures mark human regulatory chromatin
Nature Genetics (2016), 10: 1267-72
2015
- A.P. Jagtap, I. Krstic, N.C. Kunjir, R. Hänsel, T.F. Prisner, S.T. Sigurdsson
Sterically shielded spin labels for in-cell EPR spectroscopy: Analysis of stability in reducing environment
Free Radical Research (2015), 49: 78-85
2014
- R. Hänsel, L.M. Luh, F. Löhr, I. Corbeski, L. Trantirek, V. Dötsch
In-cell NMR and EPR spectroscopy of biomacromolecules
Angewandte Chemie International Edition (2014), 53: 10300-14
2013
- L.M. Luh, R. Hänsel, F. Löhr, D.K. Kirchner, K. Krauskopf, S. Pitzius, B. Schäfer, P. Tufar, I. Corbeski, P. Güntert, V. Dötsch
Molecular crowding drives active Pin1 into nonspecific complexes with endogenous proteins prior to substrate recognition
Journal of the American Chemical Society (2013), 135: 13796-803 - R. Hänsel, F. Löhr, L. Trantirek, V. Dötsch
High-resolution insight into G-overhang architecture
Journal of the American Chemical Society (2013), 135: 2816-24
2012
- R. Hänsel, S. Foldynova-Trantirkova, V. Dötsch, L. Trantirek
Investigation of quadruplex structure under physiological conditions using In-cell NMR
Topics in Current Chemistry (2012), 330: 47-65
2011
- I. Krstić*, R. Hänsel*, O. Romainczyk, J.W. Engels, V. Dötsch, T.F. Prisner
Long Range Distance Measurements on Nucleic Acids in cells by Pulsed EPR Spectroscopy
Angewandte Chemie International Edition (2011), 50: 5070-4, - R. Hänsel, F. Löhr, S. Foldynova-Trantirkova, E. Bamberg, L. Trantirek, V. Dötsch
The parallel G-quadruplex structure of vertebrate telomeric repeat sequences is not the preferred folding topology under physiological conditions
Nucleic Acids Research (2011), 39: 5768-75
2009
- R. Hänsel, S. Foldynova-Trantirkova, F. Löhr, J. Buck, E. Bamberg, H. Schwalbe, V. Dötsch, L. Trantirek
Evaluation of parameters critical for observing nucleic acids inside living Xenopus laevis oocytes by in-cell NMR spectroscopy
Journal of the American Chemical Society (2009), 131: 15761-8
2007
- S. Reckel, R. Hänsel, F. Löhr, V. Dötsch
In-cell NMR spectroscopy
Progress in Nuclear Magnetic Resonance Spectroscopy (2007), 51: 91-101 - F. Löhr, R. Hänsel, V. Rogov, V. Dötsch
Improved pulse sequences for sequence specific assignment of aromatic proton resonances in proteins
Journal of Biomolecular NMR (2007), 37: 205-24
2006
- Z. Serber, P. Selenko, R. Hänsel, S. Reckel, F. Löhr, J.E. Ferrell, G. Wagner, V. Dötsch
Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy
Nature Protocols (2006), 1: 2701-9