Deciphering (Epi)Genome structure and stability
Laboratory For Genome Biology
Our lab explores the existence and significance of epigenome structural alterations and its impact on disease development. Hence, the structure of the genome may significantly change with age and disease development, such as cancer or degenerative diseases. Additionally, we are exploring whether defined age- or cancer-related epigenome structural alterations are of diagnostic and therapeutic value.
Selected Publications
- P. Hunold, G. Pizzolato, N. Heramvand, L. Kaiser, G. Barbiera, O. van Ray, R. Thomas, J. George, M. Peifer, R. Hänsel-Hertsch
DynaTag profiles dynamics of transcription factor-DNA binding for low-input samples and at single-cell resolution
Nat Commun (2025), https://www.nature.com/articles/s41467-025-61797-9 - A. Simonis, S. J Theobald, A. E. Koch, R. Mummadavarapu, J. M. Mudler, A. Pouikli, U. Göbel, R. Acton, S. Winter, A. Albus, D. Holzmann, M.-C. Albert, M. Hallek, H. Walczak, T. Ulas, M. Koch, P. Tessarz, R. Hänsel-Hertsch# and J. Rybniker#
Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages
Mol Syst Biol (2025), https://doi.org/10.1038/s44320-025-00093-6 - I. Hudecova*, C.G. Smith*, R. Hänsel-Hertsch*, C. Chilamakuri, J.A. Morris, A. Vijayaraghavan, K. Heider, D. Chandrananda, W.N. Cooper, D. Gale, J. Garcia-Corbacho, S. Pacey, R.D. Baird, N. Rosenfeld, F. Mouliere
Characteristics, origin, and potential for cancer diagnostics of ultrashort plasma cell-free DNA
Genome Research (2022), DOI:10.1101/gr.275691.121 - R. Hänsel-Hertsch, A. Simeone, A. Shea, W.W.I. Hui, K.G. Zyner, G. Marsico, O.M. Rueda, A. Bruna, A. Martin, X. Zhang, S. Adhikari, D. Tannahill, C. Caldas, S. Balasubramanian
Landscape of G-quadruplex DNA structural regions in breast cancer
Nature Genetics (2020), 52: 878–883 - R. Hänsel-Hertsch, D. Beraldi, S.V. Lensing, G. Marsico, K. Zyner, A. Parry, M. Di Antonio, J. Pike, H. Kimura, M. Narita, D. Tannahill, S. Balasubramanian
G-quadruplex structures mark human regulatory chromatin
Nature Genetics (2016), 10: 1267-72
*contributed equally
#co-corresponding